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GLP-1 Drugs Effects on PMR

Polymyalgia Rheumatica (PMR) | Last Active: Jul 16 2:16pm | Replies (44)

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Profile picture for randersonccc @randersonccc

@dadcue I started zepbound one year ago and the benefits have been amazing in many ways. It has helped reduce my inflammation markers. It has helped my CPAP numbers to less than 1 event per hour. It has reduced my tooth plaque by about 75%. It has helped my feeling of being in control of a healthy diet not tempted by sight or smell or thoughts of my past craves. It has let me make time for other crafts I like. And also plan healthy meals. The only negative which I can manage is it slows down the colon digestion process so I need to careful with constipation issues. Less weight less to carry around so some less pain. But I still have PMR issues but easier to manage those also. My cardiologist my pulmonologist my internist my rheumatologist all gave it a thumbs up. I’ve lost 45 pounds and I’m 78 and I could lose another maybe 10. So far I’m satisfied with the zepbound - the only negative so far with my combination of medication is the Actemra; my cholesterol went up from normal to 315. But I’ll work on that. I do not want to take statins. If anyone knows anything about Repatha please let me know as my cardiologist has recommended this. Thank you all. ☺️

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Replies to "@dadcue I started zepbound one year ago and the benefits have been amazing in many ways...."

@randersonccc

I'm so happy to read this. It validates some of the positives I have experienced since I tapered off Prednisone. I worked my way up to Wegovy with some other medications that I no longer take. That is why my endocrinologist wants me to try Zepbound for "additional benefits."

All of the things you described happened to me after Actemra allowed me to taper off Prednisone. My cholesterol level decreased when I was on Actemra alone. I took a atorvastatin for 10 years when I was on Prednisone. When Prednisone was stopped my cholesterol level was too low. My rheumatologist stopped atorvastatin because my CK level was increasing so he was worried about statin induced myopathy. My cholesterol level came down so much that I don't take atorvastatin anymore. I have also stopped 3 blood pressure medications!

I need to lose more weight. I call the extra weight the last bastion of my Prednisone side effects.

I still use CPAP some nights but not every night. I don't have the dreams where I can't breathe anymore. I doubt that I need CPAP.

@Thanks for the reply and all the information. I’m glad to hear that outbound has done so many great things for your health. It does sound like a miracle drug. Hopefully you and others taking it will be able to report significant reduction on the inflammation pain and stiffness caused by PMR enabling people to get off of prednisone and stay off it.

Hi @randersonccc, my cholesterol went up with Actemra to 278 and I managed to get it down by about 40 points but my cardiologist put me on Repatha because I can’t take statins. My cholesterol is now testing normal after just 3 injections. I have not had any side effects so far and will pray the same for you! ❤️

@randersonccc I tried three different statins but all caused a lot of pain so switched to Repatha. It worked like a dream but I had to stop because United Healthcare stopped covering it.