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← Return to High Turnover Help - Understanding my CTX/P1NP Ratio
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High Turnover Help - Understanding my CTX/P1NP Ratio
Osteoporosis & Bone Health | Last Active: Apr 1 10:47am | Replies (27)Comment receiving replies
@br03 Did you ever find out why your markers were high? Mine are very high as well. My CTX is 1,340 and my P1NP is 87. I don't have any fractures. I had prior breast cancer six years ago. My Vitamin D and PTH are normal. I have osteopenia with my left femoral neck on deca at -1.4 and lumbar spine at
-1.8. I also have chronic kidney disease stage 3b. Does anyone have any idea why my markers are so high?
Replies to "@br03 Did you ever find out why your markers were high? Mine are very high as..."
@vegada, in chronic kidney disease stage 3b or higher, CTX can sometimes be higher and harder to interpret.
Are you currently on an aromatase inhibitor as part of breast cancer treatment? That can also increase bone resorption marker CTX.
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@vegada Thanks for checking back in. I’ve learned that the biggest driver of my bone loss appears to be related to gut health issues and chronic systemic inflammation. I’m also postmenopausal, but because of the findings from the Women’s Health Study, my doctor had not previously recommended BHRT. I eventually pursued additional testing, including a GI-MAP test and baseline hormone labs, which helped identify underlying concerns and led me to start BHRT.
I know this approach may not be an option for everyone, but I highly recommend considering a functional medicine provider if possible. They can often help look more deeply at root causes rather than just managing symptoms.