I’m interested in the occurrence of late side effects. I have seen in the literature that this does occur. I have been taking Anastrozole for two years and didn’t develop significant side effects until about three months after starting treatment. I had hoped my side effects had ‘ peaked’ but still struggled on with them. After eighteen months I suddenly began to develop quite severe hand symptoms, which I thought those who experience them usually get fairly early on in therapy. It seems that these drugs are ‘ the gift that keeps on giving’ and. I am just hoping no more ‘ surprises’ pop out of the cupboard!