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GLP-1 Drugs Effects on PMR

Polymyalgia Rheumatica (PMR) | Last Active: 4 days ago | Replies (24)

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I started a GLP-1 called Wegovy soon after being referred to an endocrinologist who helped me taper off prednisone. Wegovy helped me lose about half of my Prednisone related weight gain. Now my endocrinologist is considering Zepbound for some "additional benefits."

I like my endocrinologist because I'm being educated about the effects that prednisone has on hormones throughout the body. I'm starting to learn how hormones control every body system. Hormones are an extremely complex area of medicine. My endocrinologist says prednisone has "profound effects" on the endocrine system.

I started seeing an endocrinologist when my cortisol level was too low for me to taper off Prednisone. Cortisol wasn't the only abnormal hormone level that was discovered. Now my endocrinologist is trying to restore my hormone imbalances back to normal. My endocrinologist said some things could have been done when I was still taking Prednisone. However, tapering off Prednisone is usually the "first step."

I once saw a panel discussion of rheumatologists discussing GLP-1 medications. They seemed to think they should be the ones prescribing GLP-1 medications since they were the doctors prescribing the most prednisone! I thought that was funny because I don't recall my rheumatologist ever being concerned enough to check my hormone levels.

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Replies to "I started a GLP-1 called Wegovy soon after being referred to an endocrinologist who helped me..."

@dadcue I started zepbound one year ago and the benefits have been amazing in many ways. It has helped reduce my inflammation markers. It has helped my CPAP numbers to less than 1 event per hour. It has reduced my tooth plaque by about 75%. It has helped my feeling of being in control of a healthy diet not tempted by sight or smell or thoughts of my past craves. It has let me make time for other crafts I like. And also plan healthy meals. The only negative which I can manage is it slows down the colon digestion process so I need to careful with constipation issues. Less weight less to carry around so some less pain. But I still have PMR issues but easier to manage those also. My cardiologist my pulmonologist my internist my rheumatologist all gave it a thumbs up. I’ve lost 45 pounds and I’m 78 and I could lose another maybe 10. So far I’m satisfied with the zepbound - the only negative so far with my combination of medication is the Actemra; my cholesterol went up from normal to 315. But I’ll work on that. I do not want to take statins. If anyone knows anything about Repatha please let me know as my cardiologist has recommended this. Thank you all. ☺️