@cbeard1 I started 6 mos., 12 sessions, of Folfirinox in Oct. of '23 after a diagnosis of stage 4 acinar cell pancreatic cancer. I was 74 and never was told by my oncologist that my age was an issue, but I had been going to the YMCA to swim every day for years and that may have been a factor, I don't know. I figure the more fit you are going into chemo, the better you'll tolerate it. I tolerated the Folfirinox pretty well and the side effects were diarrhea, fatigue for 2-3 days after each infusion and that aggravating pump hooked to me for 46 hrs. after the infusion. The worst side effect was painful mouth sores from the Fluorouracil med. in the Folfirinox mixture. I was down to nothing but chicken noodle soup and lost weight. The only relief I got from the mouthsores was something called "magic mouthwash" and it has to come from a compounding pharmacy. Another side effect was the start of peripheral neuropathy in my legs, feet and fingertips. Long story, but I was put on Gemcitibine/Abraxane in '25 and it pushed the neuropathy over a cliff and I lost all hair. It was tougher on me than the Folfirinox and I recommend looking into cold therapy gloves and booties during any Gemcitibine/Abraxane infusion. You do_not_want peripheral neuropathy to the degree that it's affected me. I'm only offering this info as I have so much empathy for anyone going through these two chemo regimens. Good luck.