I had my first Reclast treatment 2 days ago. I followed the advice found on this forum and took a dose of Tylenol 650mg and an antihistamine 30 minutes before the IV. I also asked my provider to do it over 60 minutes (which is not the protocol at this facility but she agreed). She also agreed to add a saline drip with it (not protocol but agreeable to her). After the IV I took Tylenol every 4 hours 3 more times that day and every 4 hours the next 2 days (4 total doses). I plan to do this tomorrow, then stop the Tylenol. No side effects so far. I felt fine the last 2 days and was able to resume normal activities. I was also very fearful for many reasons (mostly due to side effects I had heard reported on this forum). I had finished Evenity in December 2025 and had some improvement in bone density. The plan is to do once a year for 2 more years than a drug holiday.