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@dmshope I was curious about your statement about Tymlos so I did some looking into it.
"In summary, 18 months of ABL administration was associated with significant improvements in 3D-DXA-based vBMD in both cortical and cancellous compartments of the proximal femur. Although TPTD increased cortical thickness and trabecular vBMD to a similar extent as ABL, cortical vBMD remained at baseline levels."
ABL: abaloparatide
TPT: teraparatide
https://pmc.ncbi.nlm.nih.gov/articles/PMC7929959/
Tymlos actually resulted in a positive effect on cortical bone while Forteo was neutral per this study. Of course, this is just one study so if you have a reference that concludes the opposite, please let me know. I like to collect interesting studies on osteoporosis treatment. Thank you!
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@oopsiedaisy
Noted your comments on the effects of PTH meds on cortical bone as it relates to the hip - with an 18 month adminstration period.
I do not have references at the moment to give you to clarify the statisitics about PTH and long bones of the body ( arm feet legs) for the full 24 month administration, It is in the later months that the antiresportive powers overtake building aspects of the drug. I have read numerous articles and had 3 endos confirm this - along with my own expereince. I am not scientific but it has somehting to do with cortical porosity and weakened microarchecture - again this is for a full term dosing. And everyone is different - some patients may be more vulnerable to this effect. Sending prayers to us all....