@gently can I inquire, what is PMR? I was told the same about this medication remaining in your system for years! It has been 21 months for me. Yes the symptoms seem to vary as well as bother different areas of one’s body. I had a lot of harsh symptoms, shoulders, left foot, nausea, flu like symptoms and blurred vision. Some of the symptoms have decreased in intensity yet still remain. I did the prednisone taper medication and really did not seem to do anything. I do know that I’ll never receive another infusion of any kind. It does affect people differently. Not sure if one’s health and prior medical issues play a part; wish there were a lot more studies to better provide to patients because I had none of these symptoms prior. However, I have had Ankolosing spondylitis for some 50 + years and bladder cancer 5x in the last 16 years; not sure if this played a part in my continued symptoms from the Reclast. I am a male, 69 years old, 5’2” about 119 lbs. they say I have degenerative disc disease in my lower back…of course, handling logs for the past 45+ years evidently played no part; I guess. Just Remember! We are our own advocates! Review treatments and medications before agreeing! Best of luck!