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Tymlos and feet/cortical bone

Osteoporosis & Bone Health | Last Active: Jul 8 1:14pm | Replies (9)

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Profile picture for dmshope @dmshope

You are correct; tymlos does help heal foot fractures but after 14-18 moths starts to negatively effect cortical bone ( which is the primary type of bone in the feet); for some peo ple this is a big problem. Forteo even more so than Evenity will effect cortical bone.
Now these are very good drugs - they just need to be understood and monitered well for a specific condition. we are all very different
I had mutilpe bilateral foot fratures ( over 8) and was put on tymlos which helped; until about 14-16 month when it started to actually weaken my feet. W did not at that time understand the negative efffects of tymlos for my cortical bone & feet. Now Dexa does not assess feet. YOu can have a CT scan as baseline and after a year ask an orthopeiditc to measure the' hounsfieldunits' - but I am not sure you will actually learn much. I did this but how I felt in my feet was just as good a gage of how stable the feet were. (There is also quantitive CT - but I have no idea where you get this - or what you might learn to actually help you)
Now that said I was screened for gentic issues and mutiple other issues early on to eliminate possibilities and reslove old imblances..
Get a very good supportive shoe - rocker front if possible to eliminate foot flex. I use Exlero Genesis II. GOod balanaced shoe.
My prpayers you find the support you need. Healing energy to you dear one.

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Replies to "You are correct; tymlos does help heal foot fractures but after 14-18 moths starts to negatively..."

@dmshope I’m so sorry to hear about your multiple foot fractures. I’ve had two stress fractures and two stress injuries. Problems with feet affect everything. I’m wondering if you might be able to connect me with any research on this I could share with my endocrinologist? How did you learn about this issue, beyond the sensations in your feet? Did your doctor agree it was from Tymlos? My feet are feeling really stable right now at 1 year full dose ( I ramped up.) I don’t want to slide backwards.

@dmshope I was curious about your statement about Tymlos so I did some looking into it.

"In summary, 18 months of ABL administration was associated with significant improvements in 3D-DXA-based vBMD in both cortical and cancellous compartments of the proximal femur. Although TPTD increased cortical thickness and trabecular vBMD to a similar extent as ABL, cortical vBMD remained at baseline levels."

ABL: abaloparatide
TPT: teraparatide
https://pmc.ncbi.nlm.nih.gov/articles/PMC7929959/
Tymlos actually resulted in a positive effect on cortical bone while Forteo was neutral per this study. Of course, this is just one study so if you have a reference that concludes the opposite, please let me know. I like to collect interesting studies on osteoporosis treatment. Thank you!