Thanks everyone for your input!!! Things settled down a bit after the initial 500 mg. However, after adding the second dose of 500 mg, Im experiencing nausea, bloating, flushing in hot weather, no appetite, etc. I checked with my doc and he suggests hanging in a bit longer; as long as I can tolerate it as Metformin is the best option for me right now.. Its been 4 weeks...yikes!