Some recent — and slightly controversial — retrospective research released this year has suggested there's no big difference among the -lutamides as far as side-effects go (there hasn't been a major comparative clinical trial on humans yet, just a hypothetical benefit that Bayer claims for Nubeqa based on in-vitro testing, and some anecdotal evidence), so take whatever you can get.

The -lutamides are somewhat more effective than Abiraterone and don't require you to take a steroid with them, which is a huge win.

The downside is that they're insanely expensive down in the U.S. (like, $12K/month or more). If your insurance will cover one, great; if not, see if any of the patient-access programmes will take you in (I was in the Erleada patient-access programme here in Canada until the Ontario Ministry of Health added Erleada/Apalutamide to its formulary in 2022).

Best of luck!