Neuropathy in Feet: B12 injections, PRP & Stem Cells?

Posted by maddie2233 @maddie2233, Sep 18, 2025

I have neuropathy in both my feet. Pain, numbness, tingling and burning. I have a massager which has a vibration mode, I apply topical solutions at night, being night time is the worse. I also had a podiatrist give me a bunch B12 injections right in my feet. It's supposed to regenerate the nerves. Tomorrow I have a Dr's appointment and I want to ask him about PRP or Stem Cell Treatment. Has anyone had either one done, or know anyone who did?
Thank you in advance for whatever information you can share...

Interested in more discussions like this? Go to the Neuropathy Support Group.

Profile picture for mrmacabre @mrmacabre

From what I've been told countless times by several doctors, nerves can not be regenerated once they're damaged or have died. End of story.

Jump to this post

Yes, I have the same problem. The nerves in my feet are getting worse. One doctor actually performed surgery on the leg for the nerves. However it didn’t work so I’m stuck here with neuropathy of legs and feet. Yes I take Lyrica 3 times a day but it doesn’t help like I wanted to.

REPLY
Profile picture for mrmacabre @mrmacabre

From what I've been told countless times by several doctors, nerves can not be regenerated once they're damaged or have died. End of story.

Jump to this post

Totally agree with you. Nothing has been shown at this point to regenerate nerves. It’s sad some Dr’s prey on people’s hopes to push this stuff. I guess there’s always the possibility the placebo effect can work.

REPLY

My new foot dr mentioned about giving me B12 shots in my feet but she wants to hear from my vascular dr because I have poor blood flow in my feet also.Has anyone heard of this being done?

REPLY
Profile picture for linmary358 @linmary358

My new foot dr mentioned about giving me B12 shots in my feet but she wants to hear from my vascular dr because I have poor blood flow in my feet also.Has anyone heard of this being done?

Jump to this post

@linmary358,

I combined your discussion with an existing discussion on foot neuropathy and different treatment options for it including b12 shots. @maddie2233 started the discussion:

"Neuropathy in Feet: B12 injections, PRP and Stem Cells?"
- https://connect.mayoclinic.org/discussion/feet-neuropathy-1/

REPLY
Profile picture for maddie2233 @maddie2233

The podiatrist gave me B12 injections directly in the feet. Each week I would go in and he would inject one foot at a time. I didn't take any B12 supplements.

Jump to this post

@maddie2233
Did the shots help? My podiatrist wants to start the shots.

REPLY

I spent a few minutes trying to find scientific articles about B12 injections in the feet for PN. I couldn't find any. That doesn't mean they don't exist.
So, the following is just my opinion. It doesn't make sense to me that this should be effective.
Unless you have a problem absorbing B12, and thus a low B12 level (which can easily be checked) there is no need to take supplemental B12 in any form, much less direct injections into the feet.
Before getting these injections, you should check with a neurologist, or your family physician.
PN is a complicated and poorly understood disease. Some people are able to make money off it for that reason. Be careful and good luck.

REPLY

Thanks for the info. I am continually looking for ways to get relief but like you said there is all kinds of folks trying to sell relief only helping their back pockets

REPLY
Profile picture for kreamks1 @kreamks1

Thanks for the info. I am continually looking for ways to get relief but like you said there is all kinds of folks trying to sell relief only helping their back pockets

Jump to this post

REPLY

My wife has restless leg syndrome, which I understand is also a nerve malfunction. Even though her B12 level was in the lower end of normal her doctor prescribed B12 shots.
It didn’t cure her restless legs, but has made it significantly better (>50%)

REPLY
Profile picture for maddie2233 @maddie2233

The podiatrist gave me B12 injections directly in the feet. Each week I would go in and he would inject one foot at a time. I didn't take any B12 supplements.

Jump to this post

@maddie2233
Did the B12 injections in the feet help.
Thanks
Martin

REPLY
Please sign in or register to post a reply.