@mimf I’ve had RA for thirty years, and I couldn’t agree more with the comment above. I was stable for many years on Plaquenil. Then it’s been a rougher ride since I started biologics. I was on anti-TNF drugs (humira, embrel, Cimzia) until I developed antibodies, then tried Rinvoq, and Actemra. Actemra is an IL 6 antagonist and it seems to be working for me now. Just keep trying. Don’t get discouraged. When the biological work they are magical, but it takes time to find what works for you. Tell your doctor exactly what you’re experiencing because truly they have no other way of knowing what’s going on. Blood tests only say so much. I feel lucky now to have a very good rheumatologist with whom I have a good rapport. I think that’s the most important thing.