← Return to How does Kevzara help with PMR symptoms and pain? I am being weaned

Discussion
Comment receiving replies
Profile picture for kjoed53 @kjoed53

@joyl263
I did respond to it. The first day was amazing. I was pain free for the first time in months. The second day was also good and I slept 9 hours instead of the 5-6 I was before pred. By day 3 it was reducing the pain significantly but not eliminating it. I'm on day 4 now, having taken my pred two hours ago. My pain is significantly reduced but not gone. I don't know if I'm expecting too much or not.

Jump to this post


Replies to "@joyl263 I did respond to it. The first day was amazing. I was pain free for..."

@kjoed53 This is when you need to understand the half-life and the steady state of a drug. The half-life is the time it takes for half of a single does is eliminated from your body. The rule of thumb is that it take 5 half-lives for a drug to completely be eliminated from your system.
Steady state is the concept of the balance of drug in your system achieved between taking a dose and the elimination of the drug by the body, resulting in a stable concentration of the drug in our body.
The half-life of Kevzara is 8-10 days and the steady state is achieved 28 to 50 days after your first dose. Meaning sometime during your second month you will achieve steady state. Until you get to the steady state each dose you take means you are getting closer - once at steady state the amount of drug you eliminate naturally between doses is equal to the amount of drug you take in a single dose.
Hope this helps you set expectations and better understand how drugs work.