@seasuite I don't know if this exactly addresses your concern since I'm on a year+ vacation from Lupron rather than Orgovyx, but after maybe(?) 5 or 6 months off the Lupron, my left nipple became painful when bumped against anything or even rubbed against clothing. Recently, I noticed that problem has disappeared, but has surfaced less commonly regarding the right nipple. I *was* wondering about breast cancer, but at the moment I'm thinking it's not something to worry about. I will certainly ask my oncologist his thoughts when I'm back there, though.