Our doctor said Nubeqa and Lupron do the same thing. I have read they are different and give different results. Anyone have information on which is more effective?
You should change a doctor ASAP !!!! I am no doctor and am pretty new here but even I know by now that Lupron and Nubequa work in completely different way and have different side effects.
Lupron completely blocks production of testosterone while Nubequa blocks testosterone from adhering to cancer cells .
Must admit, I don’t think I’ve ever heard such an incorrect statement made by a doctor. Not only are the drugs very different but they make you feel very different.
Lupron has numerous side effects it reduces your testosterone to almost zero, Which ends your Desire for a sex life, Gives you hot flashes, Weakens your bones, Destroys your muscles, and can make some people very depressed. And that’s only the beginning.
Nubeqa Essentially has no side effects for most people and does not reduce your testosterone.
Mea culpa. I apologize to all who responded. My mind was scattered. I meant will Nubeqa be effective once Xtandi stops working. My husband has a genetic mutation CDK12 which makes cancer more aggressive and resistant to treatments. Doctor feels chemo is only next option. Pluvicto failed
Nubeqa and Xtandi are both -lutamides (as is Erleada). It's possible one will work after another fails, but I think you get the biggest benefit from the first one you take.
Mea culpa. I apologize to all who responded. My mind was scattered. I meant will Nubeqa be effective once Xtandi stops working. My husband has a genetic mutation CDK12 which makes cancer more aggressive and resistant to treatments. Doctor feels chemo is only next option. Pluvicto failed
@emteenest2
One thing to consider is switching to an ADT drug that is an agonist like Lupron or if you’ve already been on that and it didn’t work then get Orgovyx Which is an antagonist and works a little bit differently. Sometimes one or the other will work for people that have a problem.
As @northoftheborder says, It’s not real likely that Darolutamide Will work after Xtandi stops working. If you’re having problematic side effects with Enzalutamide it Is definitely worth trying switching to Darolutamide To see if it works better. It has fewer side effects for most people.
Mea culpa. I apologize to all who responded. My mind was scattered. I meant will Nubeqa be effective once Xtandi stops working. My husband has a genetic mutation CDK12 which makes cancer more aggressive and resistant to treatments. Doctor feels chemo is only next option. Pluvicto failed
@emteenest2 in my opinion as only a patient, it is difficult to provide you with good feedback, given the limited information provided. The specific stage of cancer and prior treatments are importantly to understand when providing input on recommended next trestments.
In general, for patients with CDK12 mutation, my understanding is that when Xtandi is no longer effective, oncologists typically try PARP inhibitors, Pluvicto, and Chemo.
Perhaps getting another treatment opinion from an oncologist at a treatment center of excellence would be a prudent next step, given all of the variables in making a decision and all of the information from recent studies with later stage prostate cancer patients.
@emteenest2 in my opinion as only a patient, it is difficult to provide you with good feedback, given the limited information provided. The specific stage of cancer and prior treatments are importantly to understand when providing input on recommended next trestments.
In general, for patients with CDK12 mutation, my understanding is that when Xtandi is no longer effective, oncologists typically try PARP inhibitors, Pluvicto, and Chemo.
Perhaps getting another treatment opinion from an oncologist at a treatment center of excellence would be a prudent next step, given all of the variables in making a decision and all of the information from recent studies with later stage prostate cancer patients.
@jsh327 we are currently at Sloan. Our oncologist shoots down everything we bring up. Tries one drug at a time, and i can’t see why combos wouldn’t work. I like to try the combo of Orgovyx and Nubeqa, but our doctor frowned.
Pluvicto didn’t work, possibly due to his CDK12 gene mutation. I think we will try a 2nd opinion, maybe Dana Farber.
@jsh327 we are currently at Sloan. Our oncologist shoots down everything we bring up. Tries one drug at a time, and i can’t see why combos wouldn’t work. I like to try the combo of Orgovyx and Nubeqa, but our doctor frowned.
Pluvicto didn’t work, possibly due to his CDK12 gene mutation. I think we will try a 2nd opinion, maybe Dana Farber.
@emteenest2
You need to let the doctor know that the studies have shown if you are only on ADT you have a good chance of becoming castrate resistant within two years.
If he adds an ARPI like Nubeqa That can greatly extend the time you before you become castrate resistant.
That alone is a good reason to add the drug. I became cancer resistant 2 1/2 years after being on ADT alone.
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You should change a doctor ASAP !!!! I am no doctor and am pretty new here but even I know by now that Lupron and Nubequa work in completely different way and have different side effects.
Lupron completely blocks production of testosterone while Nubequa blocks testosterone from adhering to cancer cells .
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6 ReactionsMust admit, I don’t think I’ve ever heard such an incorrect statement made by a doctor. Not only are the drugs very different but they make you feel very different.
Lupron has numerous side effects it reduces your testosterone to almost zero, Which ends your Desire for a sex life, Gives you hot flashes, Weakens your bones, Destroys your muscles, and can make some people very depressed. And that’s only the beginning.
Nubeqa Essentially has no side effects for most people and does not reduce your testosterone.
You definitely need to go to a different doctor.
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2 ReactionsI hope you misheard the doctor. Those two drugs do NOT do the same thing, not even close. Yikes.
Mea culpa. I apologize to all who responded. My mind was scattered. I meant will Nubeqa be effective once Xtandi stops working. My husband has a genetic mutation CDK12 which makes cancer more aggressive and resistant to treatments. Doctor feels chemo is only next option. Pluvicto failed
Nubeqa and Xtandi are both -lutamides (as is Erleada). It's possible one will work after another fails, but I think you get the biggest benefit from the first one you take.
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2 Reactions@emteenest2
One thing to consider is switching to an ADT drug that is an agonist like Lupron or if you’ve already been on that and it didn’t work then get Orgovyx Which is an antagonist and works a little bit differently. Sometimes one or the other will work for people that have a problem.
As @northoftheborder says, It’s not real likely that Darolutamide Will work after Xtandi stops working. If you’re having problematic side effects with Enzalutamide it Is definitely worth trying switching to Darolutamide To see if it works better. It has fewer side effects for most people.
Speak to your doctor about this.
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2 ReactionsGive the doctor a break. I think he was just simplifying it. Both keep testosterone from helping cancer cells grow.
@emteenest2 in my opinion as only a patient, it is difficult to provide you with good feedback, given the limited information provided. The specific stage of cancer and prior treatments are importantly to understand when providing input on recommended next trestments.
In general, for patients with CDK12 mutation, my understanding is that when Xtandi is no longer effective, oncologists typically try PARP inhibitors, Pluvicto, and Chemo.
Perhaps getting another treatment opinion from an oncologist at a treatment center of excellence would be a prudent next step, given all of the variables in making a decision and all of the information from recent studies with later stage prostate cancer patients.
-
Like -
Helpful -
Hug
1 Reaction@jsh327 we are currently at Sloan. Our oncologist shoots down everything we bring up. Tries one drug at a time, and i can’t see why combos wouldn’t work. I like to try the combo of Orgovyx and Nubeqa, but our doctor frowned.
Pluvicto didn’t work, possibly due to his CDK12 gene mutation. I think we will try a 2nd opinion, maybe Dana Farber.
@emteenest2
You need to let the doctor know that the studies have shown if you are only on ADT you have a good chance of becoming castrate resistant within two years.
If he adds an ARPI like Nubeqa That can greatly extend the time you before you become castrate resistant.
That alone is a good reason to add the drug. I became cancer resistant 2 1/2 years after being on ADT alone.
-
Like -
Helpful -
Hug
1 Reaction