@twessel I hear all of you loud and clear. Went on Eliquis three - four years ago and at first no problem. Last two years are not so good. Suffer from fatigue and weakness every day now. It's very hard for me to not be able to do what I enjoyed in the past (always busy with activities such as cycling, kayaking, hiking, gardening etc. Now it's a big deal just to get dinner ready! Just recently was told I have some kind of tricuspid valve problem that is serious (so I was told). Doc said fatigue and weakness probably due to tricuspid problem. Why did it take so long to decide this may be it - after all the EKGs, scans, echos etc they are just finding this out? Anyway, I think that the Eliquis may be playing a part in this also. I want to be daring and stop the Eliquis and find out if it indeed is the root of the problem but.......almost a lose/lose proposition. Hope this makes sense. Fatigue also affects my mental state so I'm never sure if I'm doing/saying the right thing or not. Aging is hell....no cure!