I can't speak to the other drugs, but I can speak to prednisone. I was literally on a 6-day course (Day #1 six-pill dose decreasing to Day #6 one-pill dose) of it two weeks ago for a foot problem. I have had it several times before for other inflammatory and bone issues. I noticed that each time, it just kind of wrung me out a bit. I would doze in front of evening TV...something rare for me. During the day, I lacked my usual punch and energy. The day or so after my last dose of one pill, everything returned to normal. Has your husband really been on prednisone that long? I am guessing that it must be a consistent, one-pill-per-day dosing at the same lower strength???