I had anal cancer that could not be resolved with surgery because it was wrapped on my spinster muscle. was told at the time that my only option was the negri protocol. It took me a year but I finally found someone to do proton radiation. I started taking chemo, but didn't continue after a week. continued with the proton radiation only. it has been 2 years now and I am still NED. also just had my HPV 16th check and I am clear of that too, which is what the radiologist said would most likely be the case.