@lifetraveler I had also read that other things can cause the markers to elevate. this time, he took me off the exemestane for a month (side effects did improve, I was actually less short of breath on exercise, able to get 6-7 hours sleep) and he rechecked in 6 weeks. Last time they elevated, was slowly over about 5 months then dropped back down within 1 month. This time, he gave it the 6 weeks before ordering the tests but it stayed elevated. Specifically asked if anything else could have caused it and he said in this case no. Felt we needed to look further and ordered the tests. Had recheck blood done this week and still elevated, see him Monday. He indicated he would want to do more tests (colonoscopy - but had one 2yrs ago) but as I said, not sure I want to pursue going through a bunch more tests without a clearer path on where to look. See PCP in May so will also see what he says. Not sure if less stress to live with this and not know (and constantly wonder) or to go through all the tests trying to find something. I do appreciate your comment and to clarify I actually did read that about the markers.