I have been on Anoro for a couple of years. I was given Trelegy as a free sample whch s basically the same, but it didn't really do anything better than the Anoro. My biggest problem with Anoro is the cost.....I have insurance but I still end up with a couple hundred a month to pay. Otherwise, not sure what your question is, works fine for me, stage 4, on O2 24/7.