I started on 15 mg prednisone because my rheumatologist wasn't yet sure of the diagnosis but knew I had an inflammatory condition. That dosage just took the edge off the pain. After being diagnosed he put me on 25 mg prednisone. For context, I'm 6'3" and 245#. I'm on day 2 and most of my pain and stiffness are gone. We're all different in size, shape and how well prednisone works. Another thing to consider is switching to prednisolone because maybe your body is not converting the prednisone efficiently.