My doctor told me emphatically that I could not use my lamira (from ARIKAYCE ) with saline! I secretly tried it….. but I listened to her and only did it once. So now that I’m finished with the ARIKAYCE I see others using the pari rapid-e. I called the company and they said the hand pieces are different and they made one for use with other drugs and saline. I ordered one (it was almost $200) and upon examination it is almost identical to the hand pieces that came with the ARIKAYCE ! Lucky I saved all mine as they sent you a new one every month. I still haven’t told doctors about this! But I use it to nebulize saline almost daily! Blessings to you!