@anything4him
I switched to Nubeqa (Darolutamide) After being on Zytiga (abiraterone) for 2 1/2 years. I didn’t fail Zytiga, It just caused too many problems with my heart. Switching to Nubeqa At that point is the optimal time to do it because when zytiga fails to work for you, you are a little less likely to have the lutamide be successful in keeping your PSA down. Switching to Nubeqa In that situation is successful for about 60% of people In keeping their PSA undetectable.

So the thing to do is not stay on Zytiga Too long, Switched over to the lutamides while it is still keeping your PSA suppressed.

It did give me 2 1/2 years more time with an aggressive cancer case.

Here is an article about optical sequencing of the drugs
https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(19)30688-6/abstract
cid=c2dca8aa74&mc_eid=99575fc699