Abiraterone and prednisone can cause this problem. One guy I was working with Would wake up in the morning and have to go back to sleep for three hours because he was so exhausted.

What happens with abiraterone and prednisone Is that the Abbie reduces the cortisol and makes you have a lot of fatigue, The prednisone restores the cortisol. The problem is that Prednisone doesn’t increase cortisol enough for everybody. The recommended dosage of prednisone is 5mg or 10 mg. Some doctors start off with 10 mg but most start with five.

I had the guy I was working with talk to his doctor about increasing his prednisone to 10 mg, The doctor agreed, and a lot of the fatigue problems went away.

I was at an online conference and one of the doctors was talking about his problems with prostate cancer. He was on abiraterone And had a lot of fatigue. He increased his prednisone to 7 1/2 mg and it helped a lot, but in his case, it caused his blood sugar to increase too much and became prediabetic so he had to cut back down.

Most people do not have this problem, but I’ve just mentioned it to make you aware of it.

Ask your doctor about increasing the prednisone, It can really help.