I had a lot of foot and ankle swelling in the hospital. It got worse after hepatic artery embolization, which caused high fever and kept me from walking for several days. Was on IV then and fluids got so bad near the lungs that I needed thoracentesis to remove fluids so I could breathe (this happened twice in hospital, a 3rd time after discharge).
Swelling remained while on chemo, prednisone and diazoxide. Finally a consulting oncologist (god bless her) went through my whole meds list, told me to get rid of this, taper off that and see what happens. That plus getting active again (walking and as soon as possible bicycling) got the swelling under control.
She also reduced my chemo dose (still got sick) and got me interviewed for PRRT at another hospital.