Have not been on letrozole (yet). Say “yet” because it’s the next consideration. Initially Anastrazole and did develop the nasty bone/joint pain. While there was generalized tolerable back and hip aches, the pain was stabbing and moved around. At times bad enough that I had to take something or be immobile for the day(or both). Also elevated cholesterol levels and osteopenia. Switched to exemestane and while still a little achy in hips and back, no additional pain. Osteopenia controlled, last dexa was normal, cholesterol back to normal. Main side effects with this are extreme fatigue, weakness and insomnia. The fatigue started first at about 4 months, insomnia 3 months later. So now I require a short rest late afternoon every day (can’t sleep, just lay down and try to relax) and usually average 4 hrs sleep a night. The “weakness” could just be a factor of all this but I just can’t do what is was able to do a year ago. He’s talking about letrozole now but I’ve declined because it seems to be the worst of the bunch. Also considering asking if I can just stop it because not really sure I consider this quality of life and feel it’s aging me exponentially. But concerns because tumor markers won’t go to normal and will periodically spike back to where they were before surgery. So there are side effects to all these and different for everyone with some having none at all.