I did 3 months of Lupron and 3 months of Orgovyx. Orgovyx was easier as I developed anemia on Lupron. My bloodwork was back to normal after my course of Orgovyx and started feeling better 3 weeks after completion. 2 grade one hot flashes so was a fortunate one. For me radiation totally sucked. I suspect the techs hit me with less than a full bladder a few times causing severe bladder inflammation and proctitis. Many of the guys here have breezed through all of this.