Connect
← Return to Does anyone know, if Tymlos is causing the fat gain?
Discussion
Does anyone know, if Tymlos is causing the fat gain?
Osteoporosis & Bone Health | Last Active: 1 hour ago | Replies (33)Comment receiving replies
from internet:
Abaloparatide (Tymlos) is a synthetic analog of human parathyroid hormone-related protein (PTHrP) used to treat osteoporosis, which can cause an increase in abdominal fat and body weight. The mechanism is linked to it's (action) on calcium levels, metabolism, and parathyroid hormone pathways.
Key Reasons for Increased Fat Cells/Abdominal Fat:
Parathyroid Hormone (PTH) Effects on Fat Cells: Similar to other PTH treatments, abaloparatide can influence adipogenesis (the formation of fat cells) and fat metabolism. Increased fat mass in these cases is often specifically associated with an increase in abdominal adipose tissue.
National Institutes of Health (.gov)
Reduced Fat Cell Death (Apoptosis): High levels of calcium in the blood, which can be induced by parathyroid hormone therapies, are thought to prevent fat cell apoptosis (the natural death of fat cells).
Metabolic Shift: While intended for bone building, PTHrP (1-34) analogs like abaloparatide are involved in adipose tissue remodeling.
National Institutes of Health (.gov)
Secondary Effects: Studies have shown that changes in body composition, including increases in fat mass, can occur, and this has been observed in patients as "abdominal thickening" associated with PTH treatment.
While abaloparatide is effective for increasing bone mineral density and reducing fracture risk, its influence on adipose tissue is a recognized aspect of its metabolic impact.
National Institutes of Health (.gov)
+1
Replies to "from internet: Abaloparatide (Tymlos) is a synthetic analog of human parathyroid hormone-related protein (PTHrP) used to..."
Connect
@zygote
This is very good infor thank you. I was on tymlos 22 months and gained 8 pounds. Now that said, I was thin - and I liked how I looked (loved my clothes) but was indeed trim and very thin. I must admit, it was not a healhty weight . All my life I could not gain wieght; always having to work at keeping weight.
SInce tymlos, I no longer have to work at keeping weight but I am also eating better.
First off, dense bones weigh more then fragile bones. I know tymlos wieght seems to all be in the belly ( and I was at first sad about my flabby belly) but some if it, is in the bones.
However Let me offer another perspective. In ayurveda ( sister science to yoga /holistic health system of India) fat tissue ( meda dhatu) and bone tissue ( asthi dhatu) are distinct yet directly related to each other;Bone being dependent on healhty fat. Fat tissue acts as a direct source of nutrition for the bones. Think about that... think about all the thin frail women in toruble with their bones / in the offices getting the dexas... Anyway - fat must be in a healthy amount in the body and from healthy foods - healhty fats in the diet ( preferabley with some ghee ). I am not replying in this message about diet - but diet must be a prime component to osteo managment. Hope this helps understadn the fat/bone connection..... and come to peace with the new feeling about how you look and that you are not fracturing. Sending postive energy for yourpath to restored healht.