John answered your question about the weather. About the possibility of your appointments being canceled, I doubt it. I can not remember a time when Mayo Rochester closed due to weather. Granted, some staff may have trouble making it to work, but the staff who are there can usually accommodate the patients who show up.

In addition to what John mentioned, I would download the MN 511 app, which will have the latest road conditions. Most states have similar apps.

Also, I would pack a "Winter Survival Kit" in your car. WI Dept of Transportation site has a good list of what to include:
https://wisconsindot.gov/Pages/safety/education/winter-drv/survival-kit.aspx
If will be drving in snow, make sure you have good wiper blades on the car before leaving home.

I have one in my car from Nov to April and, luckily, have never had to use it, but good to know I have it in case of an emergency.

Drive safe