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What if this prevents cancer from becoming resistant?
Prostate Cancer | Last Active: 6 hours ago | Replies (41)Comment receiving replies
If you go on ADT for a month, it could take three or four months before your testosterone returns so the benefit you are thinking you’re getting from doing it every other month is not going be there. When I stopped taking ADT My testosterone went from under 5 to 5 in the first month, Second months it went to seven. If you’re on Orgovyx , it might come back a little faster But alternating at every other month is not gonna give you much higher testosterone, Definitely not gonna alleviate the side effects.
A drug like Darolutamide (Nubeqa) Has almost no side effects for most people. I’ve been on it for three years and have noticed no side effects. One benefit of lutamide drugs is that they suppress the ability of testosterone to allow your cancer cells to grow. So even if you have testosterone, you can stay undetectable. I know people that are on this drug all by itself because it keeps their cancer under control. If you have real high testosterone, that might be a problem. I know a couple of dozen people on this drug and they just don’t have side effects problems. I’m not saying side effects are impossible, but they are very infrequent.
The other lutamides do have more side effects So alternating them may help. You would have to see what your PSA test shows.
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@jeffmarc
Thanks, Jeff.
What if we repeat the combination for 2 or 3 months? And add an additional variation.
Look at this
Cycle 1
2 months - ADT only (decrease testosterone)
2 months - ADT + lutamide (decrease testosterone and reduce "ignition")
3 months - lutamide only (reduce "ignition" increase testosterone)
1 month - no ADT no lutamide ( "let cancer think that wall is no exist ")
Cycle 2
2 months - ADT + lutamide (decrease testosterone and reduce "ignition")
3 months - ADT only (decrease testosterone)
1 month - no ADT no lutamide ( "let cancer think is wall no exist ")
1 month - no ADT no lutamide ( "let cancer think that wall is no exist ") 2 months - lutamide only (reduce "ignition" increase testosterone)
Cycle 3
2 months - ADT + lutamide (decrease testosterone)
1 month - no ADT no lutamide ( "let cancer think that wall is no exist ")
2 months - lutamide only (reduce "ignition" increase testosterone)
3 months - ADT only (decrease testosterone)
....
Cycle 4 (New combination)
Each line can be linked to a PSA increase. As I already mentioned, if the increase is small, the lines are swapped; if the increase is significant, we increase "protection" by using both components over a longer period.
In other words, combinations should not be repeated.
You can consider varying the duration (2-3 months) depending on the Gleason level and PSA increase, and try to find a correlation. It's clear it will be nonlinear. For example, for those with a high Gleason level, they should not go without a moderate level of protection for 3 months (level = duration and combination of ADT and lutamide).