Lupron vrs Orgovyx?

Whether Orgovyx is better about hot flashes and other side effects, that is variable from person to person. But what is not debateable at all is that your testosterone will return much faster when ending Orgovyx versus ending Lupron.

@pesquallie
While the dose seems large actually the way it works is that it is very slowly dissolved into your system. Whether you have a one month three month or six month shot it dissolves at the same speed. It’s just that you get more of the drug, but it doesn’t all dissolve at once. It dissolves slowly over the time period of the specific shot.

I’m 75. 3 years ago I had RALP and immediately started on ADT – Lupron. After the first shot in the butt I could hardly sit for days. Shots never bother me; maybe it was the nurse. After that I insisted in the arm, and that was no problem. Stayed on Lupron for a year. Side effects tolerable. As many people report, side effects vary drastically from one individual to the next.
After a year off of ADT, my PSA was rising, so started up again with Lupron. Did a bunch of research comparing Lupron and Orgovyx and opted to make the switch halfway through the year. My greatest reason for making the switch is that Orgovyx (relugolix) is shown to have a lower risk of major cardiovascular events that Lupron (leuprolide). Beyond that I was hoping various side effects would be better - not so, for me. I can’t wait to get off these pills very soon, and see what happens.
As to specific side effects, I find it difficult attributing them to either ADT or my multitude of old age ailments.
As to cost, I never paid a penny for Lupron, but had to pay $1180 per month until I hit my Medicare out of pocket limit.
Sorry to be so wordy.

It's important to keep in mind if you have any cardio issues Orgovyx (Relugalux) is the better option. Of course discuss this with your MO or Cardiologist. Doctors seem to forget to tell patients that ADT can cause cardio issues including heart attack & strokes! After all we are in this to kill the prostate cancer not ourselves!