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Optimal Duration of Hormone Therapy

Prostate Cancer | Last Active: 3 days ago | Replies (40)

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@northoftheborder Well, if you couple that with Dr Weisserug’s (sp?) recent work on ADT, it seems now that being on ADT long term - or even being a lifer - does not lead to castrate resistance, one of the main reasons for these controversial holidays.
As @jeffmarc points out, being on ADT is hard work; there’s the lure of saying “screw it, I’m gonna die anyway so let’s eat, drink and be merry” and I totally get that mindset.
On the other hand, the disciplined approach of controlling blood pressure/diabetes with daily exercise and diet WILL keep you alive for many years.
It’s really a choice made early on and the results speak for themselves. My brief stint of 6 months on ADT gave me no ill effects because I watched what I ate religiously and I exercised like a madman. Could I do that for the rest of my life?? I don’t know if I could and I hope I never have to find out. Best,
Phil

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Replies to "@northoftheborder Well, if you couple that with Dr Weisserug’s (sp?) recent work on ADT, it seems..."

@heavyphil Yes, doublet therapy (adding an ARSI) significantly postposes castrate-resistance.

I don't quite get the "longer-term ADT leads to castrate resistance" fear.

If I had two fires in my house, a big one blazing away (castrate-sensitive cancer) and a little one smouldering somewhere I couldn't get to (a few cells that have started to develop castrate-resistance), I wouldn't tell firefighters to let the big fire burn the house down now to prevent the little one from possibly spreading in a few years. 😕