@56pan Oh yes, I have peripheral neuropathy! The Gemcitabine/Abraxane is the culprit. I had heard about cold therapy for hair loss prevention but not heard about it for neuropathy. At times I wonder if I would have much pain if it were not for the chemo neuropathy pains. Right now, it feels like someone is stabbing through my second toe on the left foot with a hot needle. I walk like a duck to keep balance. I've been off chemo since 12/18/2025 & like you, I feel the neuropathy is permanent. If you would ask me what pancreatic cancer feels like I would have to say the pain & loss of feeling in my hands & feet! I tried acupuncture for a while; it seemed to have helped at that time. I still get around without a wheelchair except for large stores like Walmart :).