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Why are dosages for estrogen suppression drugs one-size-fits-all?

Posted by gldilli @gldilli, Mar 28, 2023

Why is the dosage for Anastrozole (and any other AI) the same for everyone no matter your weight or size? Does this-one size-fits-all approach have an impact on side effects, risk of recurrence, etc. I’d like to know what the medical community has to say.

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angele2times | @angele2times | Mar 12 10:51am
In reply to @karenschmitt "@karenzm Disclaimer first: I am 69 and am just 6 months in on my cancer journey...." + (show)
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@karenzm
Disclaimer first: I am 69 and am just 6 months in on my cancer journey.
I had extreme side effects and am concerned about heart and bone health from Letrozole so I reduced dose to every other day after reading a NIH study.
I also started working with a Functional Medicine Doc who is giving me testosterone pellets (that include an AI). He also gave me a DIM supplement to remove any estrogen metabolites. Testing 6 weeks out are good, and I feel almost normal again!

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@karenschmitt

I am wondering about the same thing, what is DIM supplement? What did your oncologist say about the DIM supoplement?

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she55 | @she55 | Mar 12 11:28am
In reply to @karenschmitt "@karenzm Disclaimer first: I am 69 and am just 6 months in on my cancer journey...." + (show)
Profile picture for karenschmitt @karenschmitt

@karenzm
Disclaimer first: I am 69 and am just 6 months in on my cancer journey.
I had extreme side effects and am concerned about heart and bone health from Letrozole so I reduced dose to every other day after reading a NIH study.
I also started working with a Functional Medicine Doc who is giving me testosterone pellets (that include an AI). He also gave me a DIM supplement to remove any estrogen metabolites. Testing 6 weeks out are good, and I feel almost normal again!

Jump to this post

@karenschmitt hi Karen I had terrible joint pains afterletrozole prescribed in 2018. My breast cancer was caught early had 15 sessions of radiotherapy. I told my consultant I had no quality ty of life so stopped the drug. I have rheumatoid arthritis according to my rheumatologist be,cause, of the drug!!!!!!! Who knows if I would have got other.wise seems a coincidence. Hope you can make a good decision for you

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brightlight66 | @brightlight66 | Mar 12 3:32pm
In reply to @karenschmitt "@karenzm Disclaimer first: I am 69 and am just 6 months in on my cancer journey...." + (show)
Profile picture for karenschmitt @karenschmitt

@karenzm
Disclaimer first: I am 69 and am just 6 months in on my cancer journey.
I had extreme side effects and am concerned about heart and bone health from Letrozole so I reduced dose to every other day after reading a NIH study.
I also started working with a Functional Medicine Doc who is giving me testosterone pellets (that include an AI). He also gave me a DIM supplement to remove any estrogen metabolites. Testing 6 weeks out are good, and I feel almost normal again!

Jump to this post

@karenschmitt Those testosterone pellets sound veery interesting to me to help with bone health. Where did you find a Functional Medicine Doc who will do it?

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