Prolia then Reclast

Posted by followheart87 @followheart87, Oct 26, 2025

Hi, I have a quick question. I've been reading about people who had Prolia then transition to Reclast after they stop Prolia. My question is, why not just go on Reclast first? Why go on Prolia at all?

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Profile picture for Jayasri (Joyce) Hart @joyceh2025

@gravity3 I'm not sure what you mean by "anabolic." Can you explain, please?

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@joyceh2025 "Anabolic" meds for osteoporosis (from Google AI)
Anabolic agents for osteoporosis, such as
teriparatide, abaloparatide, and romosozumab, are specialized medications that build new bone by stimulating osteoblast activity, unlike bisphosphonates which only prevent breakdown. These, often daily or monthly injectable, agents are primarily for high-risk patients to rapidly increase bone density and reduce fracture risk.

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Profile picture for shmbrd @shmbrd

In answer to the question "why not just go on Reclast first? Why go on Prolia at all? " -- I can only say that my doctor (endocrinologist) prescribed Reclast because my insurance company does not cover Prolia. I'm 82, I have untreated osteoporosis, and have avoided medications so far. Maybe your doctor has a particular reason for this strategy. I think that one of these meds inhibits bone-destruction, and the other boosts bone-building. But I'm not sure which is which. good luck!

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@shmbrd Reclast (zoledronic acid) is an intravenous bisphosphonate administered yearly to strengthen bones and treat or prevent osteoporosis by inhibiting bone breakdown. It increases bone mineral density, reduces the risk of fractures—particularly in the hip and spine. I started this after Prolia which didn’t work for me. I had Evenity prior to Prolia.

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Profile picture for shmbrd @shmbrd

@joyceh2025 "Anabolic" meds for osteoporosis (from Google AI)
Anabolic agents for osteoporosis, such as
teriparatide, abaloparatide, and romosozumab, are specialized medications that build new bone by stimulating osteoblast activity, unlike bisphosphonates which only prevent breakdown. These, often daily or monthly injectable, agents are primarily for high-risk patients to rapidly increase bone density and reduce fracture risk.

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@shmbrd Thank you.

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Profile picture for kristie2 @kristie2

@shmbrd Reclast (zoledronic acid) is an intravenous bisphosphonate administered yearly to strengthen bones and treat or prevent osteoporosis by inhibiting bone breakdown. It increases bone mineral density, reduces the risk of fractures—particularly in the hip and spine. I started this after Prolia which didn’t work for me. I had Evenity prior to Prolia.

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@kristie2

May I ask how many shots of Prolia you had before reclast?

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