@windyshores j just want to say thank you for the tips and information. I’m sorry you and others have gone through such a horrible time to identify what may work and what doesn’t. I’ll add you are all brave in not only trying, but trying other options as well! I have severe osteoporosis in my spine and I’m 58 and a bit scared. My doctors all strongly encourage me to take Forteo shots but I want them to first tell me what genes/gene variants are associated with the bad reactions. The reason- I took Tamoxifen for breast cancer in my 40’s and would cry in pain quite often at night, it felt like deep bone and joint pain. I also many other had other adverse reactions but my point is that I learned years later people with one or more of one of the genetic variants I have do not metabolize Tamoxifen well. So I basically went through hell and the only thing I have to show for it is severe osteoporosis. So who knows what a bone drug may do. What I plan to do is beg the drug companies to study the genes involved and which variants cause an issue so we can simply test for those and find out what drug we may do best on. I don’t know why drug companies, doctors or researchers don’t feel this is important and could help direct the right drug to the right people. I will say that doctors caution that just because you have a genetic variant and/or show you may be a poor metabolizer of a specific drug doesn’t mean that you will react badly. But my pharmocogenomics test was 100% aligned with all of my negative Rx experiences . Soooooo