@caroljeand Thanks for the story and the connection to trauma. I think I need to clarify what I meant by trauma. When one gets a sprain of the ankle. An actual traumatic event like a fall or a misstep in which the ankle overly bends. That is a trauma and inflammation starts in that area of the damage. That kind of inflammation is what I meant when I referred to "healthy" or warranted inflammation. It is inflammation that is necessary to heal a wound (a trauma). On the contrary, I had shoulder and hip inflammation during my PMR experience but I never had a trauma to those areas. I do agree with you that trauma can trigger PMR and that trauma can be both a physical and psychological types of trauma. Many people in this chat room have spoken about being in an enormous stressful event(s) prior to PMR. Others have had accidents (traumas) that have brought on PMR in their opinion. An others have spoken about illnesses or vaccinations or operations that have been followed by PMR. I don't doubt them that PMR and those events have a relationship/connection. Inflammation in the right amount and in the right place(s) is a good thing. Given that, I do not see any reason for PMR inflammation! Great discussion. Yes, the genetic link is real too. I am just speaking to one of my many many cousins who is 58 and newly diagnosed. Out of 7 aunts and uncles (I have) we know of atleast 5 that had it. Many of the children (over 30 of them) of those 7 are starting to get it of late.