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Reversal of Statin-Induced Peripheral Neuropathy

Posted by jhkenn97 @jhkenn97, Sep 15, 2025

I am curious to know how long intermittent peripheral neuropathic of tingling/burning/sharp or shock-like sensations in extremities and less in torso and face after stopping a statin medication may take to subside? Medication (atorvastatin) was taken for about 16 months and symptoms of neuropathy started about 4 to 6 months ago but have been more pronounced in the past 6 weeks.

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evelynjc | @evelynjc | Sep 18, 2025
In reply to @heisenberg34 "I had lower back and buttocks pain. Pain specialist ran an EMG. Test results indicated neuropathy...." + (show)
Profile picture for heisenberg34 @heisenberg34

I had lower back and buttocks pain. Pain specialist ran an EMG. Test results indicated neuropathy. This was July 2024. At that point I had no numbness, buzzing, or pain in my legs.It was around that time I was put on statins. Around December I noticed some odd feeling in my feet. A month later there was some in my arms. In early 2025 pain showed up in my feet and back of legs.
So, was it the statins? Who knows?

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Thank you for sharing the details.

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Suz | @db72 | Sep 20, 2025
In reply to @ellesea01 "Wonder what your cardiologist will recommend. It does seem connected by how you describe the change...." + (show)
Profile picture for ellesea01 @ellesea01

Wonder what your cardiologist will
recommend. It does seem connected by how you describe the change. I hope they'll find a path back to you being more mobile. What is LDN? Does it reduce pain? I really hope your Dr's. can help you out. Take care. Air hug..!!

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@ellesea01 thank you. My cardiologist said I could go off till I see her in December.
The muscle tenderness is already going away and I’m hoping maybe I’ll get a little more strength in my legs as well. I don’t think the statins have caused my neuropathy because I’ve had it for years. I think it just made worse due to added weakness. However in the process of sorting this I also discontinued the antiviral (valacyclovir) I’ve been on for 2 years. Didn’t realize how tired and yucky it made me till I stopped. Between those two meds, my neuropathy has been much worse, so hopefully I’ll do a little better.

LDN is low dose Naltrexone. It’s done wonders for pain. It’s prescribed off label and has to be filled at a compound pharmacy. There’s discussions here about it.

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ellesea01 | @ellesea01 | Sep 21, 2025
In reply to @db72 "@ellesea01 thank you. My cardiologist said I could go off till I see her in December...." + (show)
Profile picture for Suz @db72

@ellesea01 thank you. My cardiologist said I could go off till I see her in December.
The muscle tenderness is already going away and I’m hoping maybe I’ll get a little more strength in my legs as well. I don’t think the statins have caused my neuropathy because I’ve had it for years. I think it just made worse due to added weakness. However in the process of sorting this I also discontinued the antiviral (valacyclovir) I’ve been on for 2 years. Didn’t realize how tired and yucky it made me till I stopped. Between those two meds, my neuropathy has been much worse, so hopefully I’ll do a little better.

LDN is low dose Naltrexone. It’s done wonders for pain. It’s prescribed off label and has to be filled at a compound pharmacy. There’s discussions here about it.

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Thanks for the update. Sounds like the recent Px
changes you've made have improved your symptoms. That's promising.

Appreciate the LDN meaning. I have to look up the N part.

Feeling better helps to get one feel more optimistic.

If you don’t mind, please keep in touch & I hope everything continues to improve for you.

💙

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1 reply
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Gail Richardson | @gailannr | Sep 21, 2025
In reply to @heisenberg34 "I had lower back and buttocks pain. Pain specialist ran an EMG. Test results indicated neuropathy...." + (show)
Profile picture for heisenberg34 @heisenberg34

I had lower back and buttocks pain. Pain specialist ran an EMG. Test results indicated neuropathy. This was July 2024. At that point I had no numbness, buzzing, or pain in my legs.It was around that time I was put on statins. Around December I noticed some odd feeling in my feet. A month later there was some in my arms. In early 2025 pain showed up in my feet and back of legs.
So, was it the statins? Who knows?

Jump to this post

I have neuropathy in my feet. I am on Losartan. Now I'm very concerned. My Dr. put me on it about the same time I started feeling pain in my feet. I am not wondering about the neuropathy being a side effect? I'm wondering if there are any studies on this?

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1 reply
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Suz | @db72 | Sep 21, 2025
In reply to @ellesea01 "Thanks for the update. Sounds like the recent Px changes you've made have improved your symptoms...." + (show)
Profile picture for ellesea01 @ellesea01

Thanks for the update. Sounds like the recent Px
changes you've made have improved your symptoms. That's promising.

Appreciate the LDN meaning. I have to look up the N part.

Feeling better helps to get one feel more optimistic.

If you don’t mind, please keep in touch & I hope everything continues to improve for you.

💙

Jump to this post

@ellesea01
Certainly! And if want to know a lot more about LDN, you can find everything you need to know here. It doesn’t work for everyone, but when it does it’s a game changer! https://ldnresearchtrust.org/

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2 replies
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ellesea01 | @ellesea01 | Sep 21, 2025
In reply to @db72 "@ellesea01 Certainly! And if want to know a lot more about LDN, you can find everything..." + (show)
Profile picture for Suz @db72

@ellesea01
Certainly! And if want to know a lot more about LDN, you can find everything you need to know here. It doesn’t work for everyone, but when it does it’s a game changer! https://ldnresearchtrust.org/

Jump to this post

@db72

Thank you very much. Appreciate this.

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John, Volunteer Mentor | @johnbishop | Sep 22, 2025
In reply to @gailannr "I have neuropathy in my feet. I am on Losartan. Now I'm very concerned. My Dr...." + (show)
Profile picture for Gail Richardson @gailannr

I have neuropathy in my feet. I am on Losartan. Now I'm very concerned. My Dr. put me on it about the same time I started feeling pain in my feet. I am not wondering about the neuropathy being a side effect? I'm wondering if there are any studies on this?

Jump to this post

Others have mentioned the same thing - Medication side effects: https://connect.mayoclinic.org/discussion/medication-side-effects-1/.

Here's a 2019 study - Losartan treatment attenuates the development of neuropathic thermal hyperalgesia induced by peripheral nerve injury in rats: https://pubmed.ncbi.nlm.nih.gov/30731141/

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Profile picture for ellesea01
ellesea01 | @ellesea01 | Sep 22, 2025
In reply to @db72 "@ellesea01 Certainly! And if want to know a lot more about LDN, you can find everything..." + (show)
Profile picture for Suz @db72

@ellesea01
Certainly! And if want to know a lot more about LDN, you can find everything you need to know here. It doesn’t work for everyone, but when it does it’s a game changer! https://ldnresearchtrust.org/

Jump to this post

Thank you very much.

REPLY
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bigmig | @bigmig | Mar 10 3:04pm

Have been on Crestor for about 9 years......and the past two years have noticed some neuropathy with my feet. Should I get off the Crestor for a month or two and see if that helps. In the meantime my cardiologist has put me on Ezetimbe for the past two months in conjunction with Crestor and it has decreased my LDL by an additional 33%. Can I continue with the Ezetimibe and get rid of the Crestor is my question? Might this help with the neuropathy in my feet?
Any ideas from other?

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