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← Return to Article: Half dose prostate drugs ‘controls cancer minus side effects
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Article: Half dose prostate drugs ‘controls cancer minus side effects
Prostate Cancer | Last Active: Mar 13 2:37pm | Replies (24)Comment receiving replies
One thing that wasn’t mentioned is that this does not have anything to do with ADT. This is a test based on the use of ARPI drugs, and a lot of those effects are more frequently found with abiraterone Since it reduces this testosterone even further than ADT. Hot flashes don’t happen with the lutamides Because they don’t reduce testosterone. Darolutamide doesn’t cause hot flashes or fatigue with the majority of people using it alone and joint pain is rarely happening.
They will be given either a full-dose or half-dose of four commonly used hormone drugs — abiraterone, enzalutamide, darolutamide and apalutamide
Replies to "One thing that wasn’t mentioned is that this does not have anything to do with ADT...."
@jeffmarc
I said that hot flashes don’t occur with lutamides. Must admit I’ve never heard anybody report that they’ve had a problem with them because of lutamides.
Apparently it is possible to have hot flash problems due to lutamides. I think it must be a rare situation, But it can occur. The biggest problem is with separating out what’s causing the hot flash, ADT or the lutamide.
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@jeffmarc I am not near as knowledgeable about the PC drugs and combos as you are, Jeff..however, in a hypothetical situation where someone has taken ADT ( Orgovyx) for say 18 months and has reached a NADIR of < .01 for a period of time ( high risk Gleason score + high PSA early on) do you think dropping Orgovyx and doing say 1/2 dose of Nubeqa might be advised for someone mid to late 70's or early 80's...just to keep quality of life up to tolerable point ? If PSA begins to rise, perhaps start back on an ADT?