Connect
← Return to Very interesting pathology report about cribiform
Discussion
Very interesting pathology report about cribiform
Prostate Cancer | Last Active: Mar 10 2:19pm | Replies (41)Comment receiving replies
I was a little confused by the signals I got from every doctor. I was Dx as 3+4. W/cribiform.
John’s Hopkins did 2nd opinion. One core 4+3 w/cribiform.
Treatment at Univ of Cincinnati, they reviewed slides and said 3+4. All said cribiform.
What was strange to me was that Google really said how adverse cribiform was. But the 4 doctors I got opinions from, (1 focal, 2 Ro and one MO never mentioned the cribiform.
When I pushed it, all of the doctors said “it’s a ‘bit’ more aggressive but not so much if IDC isn’t present and testing shows no PTEN loss.
I thought it was a death sentence and they all just kind of glossed over it.
This was after a Decipher which showed a 3% 10 year risk of metastasis and
- PTEN Intact
- very low hypoxia (very responsive to radiation)
- very low emt signal
Basically they all said I had a tumor with a very poor environment to proliferate. Even with cribiform.
Replies to "I was a little confused by the signals I got from every doctor. I was Dx..."
@bearcat998
If it is not large cribriform (over .25 mm) That is not nearly as risky. That may be why the doctors are not concerned about it.
@bearcat998 Good to hear someone else consulted with top doctors that didn't even bring it up. Like I mentioned in my OP I'm fortunate enough to have consulted with 2 of the top 15 COE's in the US and neither the urologist or the RO's ever mentioned it from biopsy report. This was what made me believe the chief pathologist's comment about all 4's present with "some type" of cribriform pattern.
I also did not have IDC, clear PSMA & MRI. Like you I read about cribiform on google and also thought it was a death sentence. Don't get me wrong it's definitely a negative factor to consider along with other test results.
Connect
@bearcat998 Yes, docs can seem blasé over a word that scares us to death; that simply comes from experience and the outcomes that they themselves have witnessed.
Also, there’s not exactly a Greek diner menu of treatments available, right? I mean you can almost count them on one hand, with perhaps a minor variation thrown in; so they are gonna treat a certain way no matter what, throw in a little ADT, vary how long you’re on it and go from there. To them it’s almost boring…
Phil