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Very interesting pathology report about cribiform
Prostate Cancer | Last Active: Mar 10 2:19pm | Replies (41)Comment receiving replies
@wwsmith
Unfortunately, intraductal seems to be much more difficult to Treat than cribriform.
Here is a really great video UCSF did discussing Cribriform And intraductal. They said that they found that most of the time when somebody had intraductal they also had cribriform.
They also mentioned that somebody that was 3+4 would have a five in their Gleason score if they had cribriform. Discussed in this video.
https://www.urotoday.com/video-lectures/a-journal-club-for-patients-with-prostate-cancer/video/mediaitem/4452-unfavorable-histology-classification-aims-to-reduce-unnecessary-treatment-journal-club-jesse-mckenney-cornelia-ding.html
Then there’s This article which discusses how difficult it is to treat intraductal
https://pubmed.ncbi.nlm.nih.gov/40186732/
It’s frustrating to try to help somebody that has both of these things since there are no known solutions.
Replies to "@wwsmith Unfortunately, intraductal seems to be much more difficult to Treat than cribriform. Here is a..."
@jeffmarc Great 28 min. video! Now I see the risks of the cribriform pattern, >/25 cm, and chance of metatasis.
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@jeffmarc
"It’s frustrating to try to help somebody that has both of these things since there are no known solutions."
Yes, that is why both surgeon and RT suggested taking the gland out and than if anything is left behind could be zapped more easily and thoroughly. I read some papers where they found that somehow IDC cells survive possibly hidden in those ducts - nobody knows why and how, they just found even more weird and much more mutated cells after salvage prostatectomy. I mean, we have NO doubt that we made a good choice with RP since they even found cells that were dying off - just horror all around.
And ALL of that with PSA just 5.4 before surgery ! : ((( Everybody was like "ahhh, take your time, PC grows sloooowww, nor rush, no rush " *blah blah blah and when they took it out was "Oh boy, this was done in the last moment !!! Such aggressive cancer, my goodness... " !!!