I’ve had both knees replaced since I started ADT. It was not a factor in having my first knee replacement recovery. What was a factor was that I didn’t do any weight exercise for the first six years I was on ADT. As a result my muscles were quite weakened when I had the second knee done. My first knee replacement was after being on it for three years. I recovered completely in the normal amount of time. The second knee took quite a bit longer, but once I recovered, I was able to run for the first time in many years. Previously, I would just fall on my face if I tried to run.

Dr. Chuck Roach at UCSF would be my preference. He did my brother‘s radiation and he also did the radiation for Rick Davis, 14 years ago, who started Ancan.Org A place you could get a lot of information about future treatment. They have weekly advanced prostate cancer meetings, and he attends them all. Rick has been undetectable for the 14 years since his radiation.

The estradiol patch costs a fraction of what it cost for ADT drugs. Doctors make a lot of money giving you the ADT drugs they are thousands of dollars. My Orgovyx Prescription is cost about $3000 a month. Estradiol probably would cost about $30 a month. Lupron is at least $4000 a year. As a result until the patch clinical trial was done in England, no one wanted to test it since it wasn’t financially profitable to do it. If you watch the video and messages I sent to you, you will find a lot more information.

Check out the absurd pricing somebody recently had for Lupron
https://kffhealthnews.org/news/article/bill-of-the-month-shot-prostate-cancer-drug-testosterone/
By the way, I cannot use estradiol because I have BRCA2 and it can cause breast cancer and adding estrogen can make that happen faster.

And then there’s this from a UCSF doctor

At the 11/1/2025 PCRI conference the following was said by Matthew R. Cooperberg, MD, MPH

What about focal therapy? (HIFU, TULSA PRO and Cryotherapy )
* The energy modality matters much less than the accuracy of the imaging - which is not there yet.
* Overall focal therapy is associated with minor side effects, but high rates of recurrence both in- and out-of-field.
* Focal therapy is not really a replacement for surgery or radiation; it is better considered an adjunct to active surveillance