Here's a summary on the lengthy infommercial on this product which I just watched.

Barbara O'Niel is represented to be a world-reknowned expert on neuropathic pain who developed the formula to help her husband who was suffering from acute neuropathic pain. Tom Hanks and Morgan Freeman appear to be her patients who have taken this product and swear by it, but these days you can't really tell if it's deep fake or not. Eric Clapton is also shown in the video.
Everything she says about the product sounds reasonable and "scientific." First is the claim that there is no neuropathic disease in Okinawa from which the main ingredient Okinawan circumin is derived. Circumin is found in Turmeric. Okinawa is the island well-known for its centenarian population, and she claims that Okinawan turmeric has 10X as much circumin as that found in turmeric available in the US.
The formula also includes Alpha Lipoic Acid exract as an accelerant, plus Actyl L Carnatine for myelin regeneration. A Stanford study on pain is mentioned as evidence backing the claims of this product. The famous Dr. Gundry shows up with his endorsement for the basic ingredients, as well as the involvement of a Dr. Punakship who apparently did a pain study on twins.
My suspicions were aroused when vaccine-deniers Robert Kennedy Jr. as well as Dr. Oz were mentioned as proponents of the basic concept of these "natural" ingredients.
Still, I have often that turmeric is a powerful inflammation fighter, although I've never heard that Okinawan turmeric is like Super Turmeric. (By the way, if you do take turmeric, make sure to add black pepper to improve absorbtion of the turmeric. I have recently started taking it powdered, with ginger and black pepper stirred into a small glass of orange juice.) Who knows if it does any good, but my Dr. at Johns Hopkins didn't tell me to not do that...

I am so tempted to try this Presgera stuff because I have the same symptoms O'Niel claims her husband had, and she "cured" him and many others with this formula.
Also, it makes sense to me that we haven't heard about it becaue Big Pharma would not want the general public to know that some very ubiquitous inexpensive ingredients could cut into the huge profits they make from drugs like Gabapentin, Pregabalin, etc.. There is no question that those drugs are extremely powerful, but they can cause serious side -effects (at least in my case) that make you dizzy and foggy at best, and suicidal at worst.) But Barbara O'Niel seems like a really nice, honest, smart Australian (I guess). So I'm tempted to believe her claim.

I'd love to know if anyone actually takes this product and what you think.
Beyhan
March 2026