@nycmusic Alendronate aka Fosamax also has a long halt-life in your body. But you may have meant the more immediate effects just as you take it.

Here is an article that references the half-life: Effects of Continuing or Stopping Alendronate After 5 Years of Treatment
https://jamanetwork.com/journals/jama/fullarticle/204789
Excerpt: "The terminal half-life of alendronate is similar to that of bone mineral, approximately 10.5 years."