For stage 4 kidney cancer I just started my third week of 60 mg Cabometyx. I have had a number of side effects however, so far manageable. They have included: high blood pressure (started medicine to control), fatigue, voice changes (raspy/hoarse), muscle spasms/leg cramps, weight loss and sore muscles. I have a doctor's appointment next week for a toxicity check and my next scan in 2 months.