I have been taking colestipol for 2 years to control horrific diarrhea; yup—I,used to know/plan shopping around bathrooms! My gallbladder was removed over 50,years ago. Due to joint inflammation and uveitis, I’ve been on a humira biologic for 5 months. I used to,take 2–3 colestipol /day but now,take 1 before bed. The diarrhea is gone except for an occasional flare. I do,adhere to a low-fat diet; Bile acid malabsorption is not,uncommon after gall bladder removal yet it is,under disgnosed in the US ; In fact, the testing is widely available in Europe but not in US. best wishes!