Wassersug has been using it for long time. It sounds almost ideal compared to some of the horror stories associated with the normally prescribed ADT. A drawback he points to is that every patient will have to experiment to find out how to apply an adequate dose. He says the question a lot of docs come back with if a patient presents convincing data that estradiol patches or gel is a good way to go is, what dose? He talks about very frequent testing and adjusting how much. I haven't found out how often testing would be required, and how costly all this testing might prove to be.