@harborside24 From Novartis on the internet...

Reclast (zoledronic acid) is administered via a 5 mg/100 mL intravenous infusion, which must last no less than 15 minutes, though a 30-minute infusion is often used to minimize side effects. The infusion is generally given once a year for osteoporosis treatment or every two years for prevention.
Novartis
Novartis
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30-Minute Administration Protocol
Pre-Infusion Requirements:
Hydration: Instruct the patient to drink adequate fluids within a few hours before the infusion.
Premedication: Consider consulting a healthcare professional regarding premedication with acetaminophen (Tylenol) and/or an antihistamine to minimize acute phase reactions.
Labs: Ensure serum creatinine/creatinine clearance is checked within 30 days of the visit. Do not administer if CrCl is < 35 mL/min.
Supplementation: Confirm patient has adequate calcium and vitamin D intake.
Infusion Process (30 Minutes):
Setup: Use a separate vented IV line for Reclast.
Rate: Administer the 100 mL solution over 30 minutes.
Flush: Follow the infusion with a normal saline flush.
Post-Infusion & Monitoring:
Monitoring: Monitor the patient for 15-30 minutes after the infusion for any immediate reactions.
Discharge Instructions: Advise the patient to continue adequate fluid intake for 4 days.