@harborside24 From Novartis on the internet...

Reclast (zoledronic acid) is administered via a 5 mg/100 mL intravenous infusion, which must last no less than 15 minutes, though a 30-minute infusion is often used to minimize side effects. The infusion is generally given once a year for osteoporosis treatment or every two years for prevention.
Novartis
Novartis
+4
30-Minute Administration Protocol
Pre-Infusion Requirements:
Hydration: Instruct the patient to drink adequate fluids within a few hours before the infusion.
Premedication: Consider consulting a healthcare professional regarding premedication with acetaminophen (Tylenol) and/or an antihistamine to minimize acute phase reactions.
Labs: Ensure serum creatinine/creatinine clearance is checked within 30 days of the visit. Do not administer if CrCl is < 35 mL/min.
Supplementation: Confirm patient has adequate calcium and vitamin D intake.
Infusion Process (30 Minutes):
Setup: Use a separate vented IV line for Reclast.
Rate: Administer the 100 mL solution over 30 minutes.
Flush: Follow the infusion with a normal saline flush.
Post-Infusion & Monitoring:
Monitoring: Monitor the patient for 15-30 minutes after the infusion for any immediate reactions.
Discharge Instructions: Advise the patient to continue adequate fluid intake for 4 days.

@harborside24 I have been searching for this post by @gently and finally found it. Endodoc contributes to this website as well as the Inspire website which has information about osteoporosis. This is from @gently and is for anyone whose doc is hesitant to order more than a 15 minute infusion...

I'm copying a helpful note from the md who led the trials on Reclast in case you haven't seen it.

"My strong recommendation based on my knowledge of bisphosphonates (given that I helped to develop three of them, and treated 13,000 patients in phase 3 trials with them) is to have the infusion center dilute the 5 mg of zoledronic that comes in 100 mL of D5W into 500 mL of NS, and infuse the endodoc recnow 600 mL over 60 minutes. Making the drug more dilute and administering it more slowly significantly improves the renal safety for N-containing bisphosphonates.I also strongly recommend that the infusion nurses give the patient 650 mg of acetaminophen (Tylenol) at the time of the infusion, and that the patient take that same dose with dinner and at bedtime the day of the infusion, with all 3 meals and at bedtime the day after the infusion, and a final (7th) dose of acetaminophen with breakfast the 2nd morning after the infusion. These 8 doses total of Tylenol reduce the chance of a symptomatic APR (Acute Phase Reaction) from 22% to < 1%.Best, Endodoc"